Tetrahydrofuran → 1-(4-Amino-1-methyl-1h-pyrazol-3-yl)-3,3-dimethyl-2-pyrrolidinone

Participants

Reaction Steps

A mixture of 3,3-dimethyl-1-(1-methyl-4-nitro-1H-pyrazol-3-yl)pyrrolidin-2-one (170 mg), 10% palladium-carbon (76 mg), THF (2 mL) and methanol (2 mL) was stirred at room temperature for 2 hr under hydrogen atmosphere. The reaction mixture was filtered through a membrane filter, and the filtrate was concentrated under reduced pressure to give the title compound (140 mg).

Provenance & Evidence