Hydrochloric Acid → 3-(2-Thiazolylsulfonyl)benzoic acid

HRID 632792Notes

Reaction equation

HRID 632792 reaction equation
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[S:6]([C:9]1[CH:10]=[C:11]([CH:16]=[CH:17][CH:18]=1)[C:12]([O:14]C)=[O:13])(=[O:8])=[O:7].[OH-].[Na+].Cl>CO>[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[S:6]([C:9]1[CH:10]=[C:11]([CH:16]=[CH:17][CH:18]=1)[C:12]([OH:14])=[O:13])(=[O:8])=[O:7]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 118061370HCID 118061370, compound

Product 1

HCID 1180610983-(2-Thiazolylsulfonyl)benzoic acidYield 86%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of methyl 3-(1,3-thiazol-2-ylsulfonyl)benzoate (82 mg) in methanol (1.5 mL) was added 1M aqueous sodium hydroxide solution (0.58 mL), and the mixture was stirred at room temperature for 2 hr. The reaction mixture was ice-cooled, 1M hydrochloric acid (1.0 mL) was added thereto, and the precipitate was collected by filtration to give the title compound (67 mg).

Workup

  1. temperaturecooled
  2. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-7b2e73c91fa84d0789472efcd61637da
Source dataset
uspto-grants-2016_04
Patent number
US09321757B2

Reaction notes

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