Trifluoroacetic acid → (1-(4-fluorobutyl)-1H-imidazo[4,5-b]pyridin-2-yl)methanol

HRID 632866Notes

Reaction equation

[C:1](O)([C:3](F)(F)F)=[O:2].[F:8][CH2:9][CH2:10][CH2:11][CH2:12][NH2:13].F[C:15]1[C:16]([N+:21]([O-])=O)=[N:17][CH:18]=[CH:19][CH:20]=1>>[F:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[C:15]2[C:16](=[N:17][CH:18]=[CH:19][CH:20]=2)[N:21]=[C:3]1[CH2:1][OH:2]

Participants

Reactant 3

HCID 6422Trifluoroacetic acid

HCID 27628023-Fluoro-2-nitropyridine

HCID 178630794-Fluorobutan-1-amine

Product 1

HCID 67991782(1-(4-fluorobutyl)-1H-imidazo[4,5-b]pyridin-2-yl)methanol

Procedure

Intermediate 42-5 was prepared in the same manner as intermediate 11-5 using the TFA salt of 4-fluorobutan-1-amine and 3-fluoro-2-nitropyridine as starting materials.

Sources & evidence

ORD record: ord-df15d4259db5408f8874b4845313e564
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09321767B2

Reaction notes

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