N-Iodosuccinimide → 5-Iodo-6-(trifluoromethyl)pyridin-2-amine

HRID 632878Notes

Reaction equation

HRID 632878 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[N:8]=[C:7]([NH2:9])[CH:6]=[CH:5][CH:4]=1.C1C(=O)N([I:19])C(=O)C1>>[F:11][C:2]([F:1])([F:10])[C:3]1[N:8]=[C:7]([NH2:9])[CH:6]=[CH:5][C:4]=1[I:19]

Participants

3

Reactant 2

HCID 120273N-IodosuccinimideHCID 8210242-Amino-6-(trifluoromethyl)pyridine

Product 1

HCID 580730655-Iodo-6-(trifluoromethyl)pyridin-2-amine

Procedure

The title compound is synthesized according to general procedure GP1 starting from 4.8 g (30 mmol) 6-trifluoromethyl-pyridin-2-ylamine and 6.7 g (30 mmol) NIS. Yield after precipitation from the reaction mixture and isolation of additional product from the mother liquid by chromatography in silica gel: 5.73 g (67%).

Workup

  1. customYield
  2. customafter precipitation from the reaction mixture and isolation of additional product from the mother liquid by chromatography in silica gel

Sources & evidence

ORD record
ord-d62b6d080e7848e6a031863a0b645057
Source dataset
uspto-grants-2016_04
Patent number
US09321771B2

Reaction notes

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