HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 6-Ethyl-5-ethynylpyridin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 6-Ethyl-5-trimethylsilanylethynyl-pyridin-2-ylamine | HCID 58072900 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 6-Ethyl-5-ethynylpyridin-2-amine | HCID 45078943 | — |
Reaction Steps
The title compound is synthesized according to general procedure GP3 starting from 12.23 g (56 mmol) 6-ethyl-5-trimethylsilanylethynyl-pyridin-2-ylamine and 3.87 g (28 mmol) K2CO3 in 120 mL MeOH. The product is purified by chromatography on silica gel using a DCM/MeOH gradient. Yield: 4.5 g (85%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321771B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-df4522934c0c45da8c467d45634ac21f |
| Source note | uspto-grants-2016_04 |