Potassium Carbonate → 6-Ethyl-5-ethynylpyridin-2-amine

HRID 632897Notes

Reaction equation

HRID 632897 reaction equation
[CH2:1]([C:3]1[N:8]=[C:7]([NH2:9])[CH:6]=[CH:5][C:4]=1[C:10]#[C:11][Si](C)(C)C)[CH3:2].C([O-])([O-])=O.[K+].[K+]>CO>[CH2:1]([C:3]1[N:8]=[C:7]([NH2:9])[CH:6]=[CH:5][C:4]=1[C:10]#[CH:11])[CH3:2]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 580729006-Ethyl-5-trimethylsilanylethynyl-pyridin-2-ylamine

Product 1

HCID 450789436-Ethyl-5-ethynylpyridin-2-amine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound is synthesized according to general procedure GP3 starting from 12.23 g (56 mmol) 6-ethyl-5-trimethylsilanylethynyl-pyridin-2-ylamine and 3.87 g (28 mmol) K2CO3 in 120 mL MeOH. The product is purified by chromatography on silica gel using a DCM/MeOH gradient. Yield: 4.5 g (85%).

Workup

  1. customThe product is purified by chromatography on silica gel using a DCM/MeOH gradient

Sources & evidence

ORD record
ord-df4522934c0c45da8c467d45634ac21f
Source dataset
uspto-grants-2016_04
Patent number
US09321771B2

Reaction notes

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