反应详情

[4-(4-hydroxyphenyl)cyclohexylidene]acetic acid methyl ester (29 g, 0.12 mol) and 10% pd/c (2.9 g) were put into ethyl acetate and stirred under 25° C. hydrogen gas for 24 hours. The reaction mixture was filtered with celite and concentrated in the vacuum to obtain a yellow solid. The mixture was dissolved in hot ethyl acetate (29 mL) and cooled to reach ambient temperature. The reaction mixture was cooled with ice water again, a filtrate was filtered and washed with ethyl acetate (15 mL) to obtain trans [4-(4-hydroxyphenyl)cyclohexyl]acetic acid methyl ester as a white solid (12.6 g, 43%).

1. filtrationThe reaction mixture was filtered with celite and
2. concentrationconcentrated in the vacuum
3. customto obtain a yellow solid
4. temperaturecooled
5. customto reach ambient temperature
6. filtrationa filtrate was filtered
7. washwashed with ethyl acetate (15 mL)