Isopropylamine → N1-(4-chloro-3-(pyridin-2-yl)phenyl)-N4-isopropylterephthalamide

HRID 633042Notes

Reaction equation

HRID 633042 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[CH:19]=[CH:18][C:14]([C:15]([OH:17])=O)=[CH:13][CH:12]=2)=[O:10])=[CH:4][C:3]=1[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=1.[CH:26]([NH2:29])([CH3:28])[CH3:27]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:10])[C:11]2[CH:19]=[CH:18][C:14]([C:15]([NH:29][CH:26]([CH3:28])[CH3:27])=[O:17])=[CH:13][CH:12]=2)=[CH:4][C:3]=1[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=1

Participants

3

Reactant 2

HCID 6363IsopropylamineHCID 668778874-(4-Chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid

Product 1

HCID 58614667N1-(4-chloro-3-(pyridin-2-yl)phenyl)-N4-isopropylterephthalamide

Procedure

50 mg of 4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to isopropylamine via Procedure G. The product was purified on reverse phase HPLC to yield N1-(4-chloro-3-(pyridin-2-yl)phenyl)-N4-isopropylterephthalamide. MS (Q1) 394 (M)+.

Workup

  1. customThe product was purified on reverse phase HPLC

Sources & evidence

ORD record
ord-8ac290f4df7648888783130130558d22
Source dataset
uspto-grants-2016_04
Patent number
US09321761B2

Reaction notes

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