Acetonitrile → 3-(6-(Cycloheptyloxy)pyridin-2-yl)-3-oxopropanenitrile

HRID 63340Notes

Reaction equation

HRID 63340 reaction equation
[CH:1]1([O:8][C:9]2[N:14]=[C:13]([C:15]([O:17]C)=O)[CH:12]=[CH:11][CH:10]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:19][C:20]#[N:21]>>[CH:1]1([O:8][C:9]2[N:14]=[C:13]([C:15](=[O:17])[CH2:19][C:20]#[N:21])[CH:12]=[CH:11][CH:10]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 6342AcetonitrileHCID 86694648HCID 86694648, compound

Product 1

HCID 866946473-(6-(Cycloheptyloxy)pyridin-2-yl)-3-oxopropanenitrile

Procedure

CH3CN addition to methyl 6-(cycloheptyloxy)picolinate following the method described in Example 6 gave 3-(6-(cycloheptyloxy)pyridin-2-yl)-3-oxopropanenitrile as a yellow oil which was used in the next step without further purification. Yield (1.29 g, quant.).

Sources & evidence

ORD record
ord-3d6fee8f8d0d47a6a1166ee2fe3b8b62
Source dataset
uspto-grants-2016_09
Patent number
US09447078B2

Reaction notes

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