Acetonitrile → HCID 86694651, compound

HRID 63343Notes

Reaction equation

HRID 63343 reaction equation
[CH3:1][C:2]#[N:3].[CH2:4]([O:6][C:7]([N:9]1[CH2:14][CH2:13][CH:12]([CH2:15][O:16][C:17]2[N:22]=[C:21]([C:23](OC)=[O:24])[CH:20]=[CH:19][CH:18]=2)[CH2:11][CH2:10]1)=[O:8])[CH3:5]>C(OCC)(=O)C>[C:2]([CH2:1][C:23]([C:21]1[N:22]=[C:17]([O:16][CH2:15][CH:12]2[CH2:13][CH2:14][N:9]([C:7]([O:6][CH2:4][CH3:5])=[O:8])[CH2:10][CH2:11]2)[CH:18]=[CH:19][CH:20]=1)=[O:24])#[N:3]

Participants

4

Reactant 2

HCID 6342AcetonitrileHCID 86694652HCID 86694652, compound

Product 1

HCID 86694651HCID 86694651, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

CH3CN addition to methyl 6-((1-(ethoxycarbonyl)piperidin-4-yl)methoxy)picolinate following the method described in Example 6 gave ethyl 4-(((6-(2-cyanoacetyl)pyridin-2-yl)oxy)methyl)piperidine-1-carboxylate in ethyl acetate solution which was used in the next step without further purification.

Sources & evidence

ORD record
ord-78690bed092840639f60f3abf5c5ab28
Source dataset
uspto-grants-2016_09
Patent number
US09447078B2

Reaction notes

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