HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene, 1-fluoro-2-methyl-4-nitro- → Tert-butyldimethyl(2-(2-methyl-4-nitrophenoxy)ethoxy) silane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene, 1-fluoro-2-methyl-4-nitro- | HCID 68001 | — |
| Reactant | 2-(tert-Butyl(dimethyl)silyl)oxyethanol | HCID 11137665 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Reactant | 2-(2-chloro-4-((4-(((7R,8aS)-5,5-dimethyloctahydroindolizin-7-yl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)ethan-1-ol | HCID 71811286 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Tert-butyldimethyl(2-(2-methyl-4-nitrophenoxy)ethoxy) silane | HCID 86704536 | — |
Reaction Steps
A similar procedure as detailed above for Compound 133 was used. 2-fluoro-5-nitrotoluene (310 mg, 2.0 mmol), potassium tert-butoxide (494 mg, 4.4 mmol) and 2-((tert-butyldimethylsilyl)oxy)ethan-1-ol (705 mg, 4.0 mmol) in THF (6 mL) was stirred for 3 hr at room temperature to give the product after workup (yield assumed quantitative=623 mg). The product was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321763B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-3516749a84db4a139303a24f6700fe7c |
| Source note | uspto-grants-2016_04 |