反应详情

A round-bottom flask was charged with 2-(4-isopropylpiperazin-1-yl)-5-nitrobenzonitrile (1.76 g, 6.42 mmol), EtOH (65 mL), and 10% Pd/C (50% in water, Degussa type E101; 355 mg, 20 wt % by weight of the starting nitro compound). The flask was sealed with a rubber septum, degassed, and back-filled with H2 (×3) from a balloon filled with H2. The reaction was stirred for 2 h using a H2 filled balloon. The reaction mixture was filtered through a pad of celite, and the pad of celite was rinsed with MeOH. The filtrate was evaporated to dryness, and the product dried in vacuo to provide 5-amino-2-(4-isopropylpiperazin-1-yl)benzonitrile (1.49 g, 95% yield) as a yellow solid that was used without further purification.

1. customThe flask was sealed with a rubber septum
2. customdegassed
3. additionback-filled with H2 (×3) from a balloon
4. additionfilled with H2
5. filtrationThe reaction mixture was filtered through a pad of celite
6. washthe pad of celite was rinsed with MeOH
7. customThe filtrate was evaporated to dryness
8. customthe product dried in vacuo