反应详情

The product from Example 44A (0.1 g, 0.302 mmol), cyclopropanecarboxaldehyde (0.063 g, 0.905 mmol) and sodium triacetoxyhydroborate (0.192 g, 0.905 mmol) were combined in dichloromethane (1.0 mL) and acetic acid (1.0 mL) under nitrogen, stirred for 6 hours and partitioned into water/ethyl acetate. The organic layer was washed with 5% aqueous sodium bicarbonate, saturated aqueous sodium chloride, dried (anhydrous Na2SO4), filtered, and concentrated to afford the title compound (0.116 g, 100%).

1. custompartitioned into water/ethyl acetate
2. washThe organic layer was washed with 5% aqueous sodium bicarbonate, saturated aqueous sodium chloride
3. dry with materialdried (anhydrous Na2SO4)
4. filtrationfiltered
5. concentrationconcentrated