HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium methanethiolate → 3-Bromo-2-(2,4-difluorophenoxy)-5-(methylthiomethyl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium methanethiolate | HCID 4378561 | — |
| Reactant | 3-Bromo-5-(bromomethyl)-2-(2,4-difluorophenoxy)pyridine | HCID 86721076 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-Bromo-2-(2,4-difluorophenoxy)-5-(methylthiomethyl)pyridine | HCID 86721077 | 96.3% |
Reaction Steps
The product from Example 60C (0.75 g, 1.979 mmol) and sodium thiomethoxide (0.139 g, 1.979 mmol) were combined in dimethylformamide (3.96 mL), stirred for 4 hours and partitioned into ethyl acetate and cold water. The organic layer was washed with saturated aqueous sodium chloride, dried (anhydrous Na2SO4), filtered, and concentrated to afford the title compound (0.66 g, 96%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321764B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-cf4598693ca34dc095286c6837bfb2c1 |
| Source note | uspto-grants-2016_04 |