2-Bromoaniline → HCID 43560304, compound

HRID 633591Notes

Reaction equation

HRID 633591 reaction equation
[Br:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].N1CCC(NC(=O)O[C:18]([CH3:21])([CH3:20])[CH3:19])CC1>>[Br:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH:4][CH2:19][CH:18]1[CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 119922-BromoanilineHCID 7238334-(N-Boc-amino)piperidine

Product 1

HCID 43560304HCID 43560304, compound

Procedure

Example 142A was prepared as described in Example 111A substituting cyclopropanecarbaldehyde for Example 105B and 2-bromoaniline for tert-butyl piperidin-4-ylcarbamate. The isolated product was purified by flash chromatography (silica gel, 0-10% ethyl acetate in heptane) to give the title compound.

Workup

  1. customExample 142A was prepared
  2. customThe isolated product was purified by flash chromatography (silica gel, 0-10% ethyl acetate in heptane)

Sources & evidence

ORD record
ord-74b441168d33442bb0500058f90799bf
Source dataset
uspto-grants-2016_04
Patent number
US09321764B2

Reaction notes

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