Trifluoroacetic acid → HCID 71203156, compound

HRID 633620Notes

Reaction equation

[CH3:1][C:2]1[CH:16]=[C:15]([C:17]2[O:18][C:19]3[N:20]=[C:21]([O:29][CH2:30][CH2:31][C:32]([F:35])([F:34])[F:33])[N:22]=[C:23]([CH2:26][CH2:27][CH3:28])[C:24]=3[N:25]=2)[CH:14]=[C:13]([CH3:36])[C:3]=1[O:4][CH2:5][C:6]([O:8]C(C)(C)C)=[O:7].FC(F)(F)C(O)=O>>[CH3:36][C:13]1[CH:14]=[C:15]([C:17]2[O:18][C:19]3[N:20]=[C:21]([O:29][CH2:30][CH2:31][C:32]([F:35])([F:34])[F:33])[N:22]=[C:23]([CH2:26][CH2:27][CH3:28])[C:24]=3[N:25]=2)[CH:16]=[C:2]([CH3:1])[C:3]=1[O:4][CH2:5][C:6]([OH:8])=[O:7]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 71203162HCID 71203162, compound

Product 1

HCID 71203156HCID 71203156, compoundYield 103%

Procedure

Analogously to example 1 (j), the reaction of 12 mg of tert-butyl {2,6-dimethyl-4-[7-propyl-5-(3,3,3-trifluoropropoxy)oxazolo[5,4-d]pyrimidin-2-yl]phenoxy}acetate with trifluoroacetic acid gave 11 mg (83%) of the title compound.

Sources & evidence

ORD record: ord-b8b70ebfc0ce45598123fa3a519647a0
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09321787B2

Reaction notes

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