2-Fluorophenol → HCID 71186578, compound

HRID 633622Notes

Reaction equation

HRID 633622 reaction equation
[CH2:1]([C:5]1[C:6]2[N:17]=[C:16]([C:18]3[CH:32]=[C:31]([CH3:33])[C:21]([O:22][CH2:23][C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])=[C:20]([CH3:34])[CH:19]=3)[O:15][C:7]=2[N:8]=[C:9](S(C)(=O)=O)[N:10]=1)[CH:2]([CH3:4])[CH3:3].[F:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=1[OH:42]>>[F:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=1[O:42][C:9]1[N:10]=[C:5]([CH2:1][CH:2]([CH3:4])[CH3:3])[C:6]2[N:17]=[C:16]([C:18]3[CH:32]=[C:31]([CH3:33])[C:21]([O:22][CH2:23][C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])=[C:20]([CH3:34])[CH:19]=3)[O:15][C:7]=2[N:8]=1

Participants

3

Reactant 2

HCID 97072-FluorophenolHCID 71187216HCID 71187216, compound

Product 1

HCID 71186578HCID 71186578, compoundYield 100%

Procedure

Analogously to example 1 (i), the reaction of 60 mg of tert-butyl [4-(7-isobutyl-5-methanesulfonyloxazolo[5,4-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]acetate with 2-fluorophenol gave 64 mg (100%) of the title compound.

Sources & evidence

ORD record
ord-b2a034151e484b05b13e2543f66e7eb5
Source dataset
uspto-grants-2016_04
Patent number
US09321787B2

Reaction notes

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