Trifluoroacetic acid → HCID 71203166, compound

HRID 633623Notes

Reaction equation

HRID 633623 reaction equation
[F:1][C:2]1[CH:38]=[CH:37][CH:36]=[CH:35][C:3]=1[O:4][C:5]1[N:6]=[C:7]([CH2:31][CH:32]([CH3:34])[CH3:33])[C:8]2[N:13]=[C:12]([C:14]3[CH:28]=[C:27]([CH3:29])[C:17]([O:18][CH2:19][C:20]([O:22]C(C)(C)C)=[O:21])=[C:16]([CH3:30])[CH:15]=3)[O:11][C:9]=2[N:10]=1.FC(F)(F)C(O)=O>>[F:1][C:2]1[CH:38]=[CH:37][CH:36]=[CH:35][C:3]=1[O:4][C:5]1[N:6]=[C:7]([CH2:31][CH:32]([CH3:34])[CH3:33])[C:8]2[N:13]=[C:12]([C:14]3[CH:28]=[C:27]([CH3:29])[C:17]([O:18][CH2:19][C:20]([OH:22])=[O:21])=[C:16]([CH3:30])[CH:15]=3)[O:11][C:9]=2[N:10]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 71186578HCID 71186578, compound

Product 1

HCID 71203166HCID 71203166, compoundYield 57.8%

Procedure

Analogously to example 1 (j), the reaction of 64 mg of tert-butyl {4-[5-(2-fluorophenoxy)-7-isobutyloxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy}acetate with trifluoroacetic acid gave 33 mg (56%) of the title compound.

Sources & evidence

ORD record
ord-13bd24e6efe04496a1ba8dfff72d9ad8
Source dataset
uspto-grants-2016_04
Patent number
US09321787B2

Reaction notes

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