Trifluoroacetic acid → HCID 71203163, compound

HRID 633625Notes

Reaction equation

[CH2:1]([C:5]1[C:6]2[N:20]=[C:19]([C:21]3[CH:35]=[C:34]([CH3:36])[C:24]([O:25][CH2:26][C:27]([O:29]C(C)(C)C)=[O:28])=[C:23]([CH3:37])[CH:22]=3)[O:18][C:7]=2[N:8]=[C:9]([O:11][CH2:12][CH2:13][C:14]([F:17])([F:16])[F:15])[N:10]=1)[CH:2]([CH3:4])[CH3:3].FC(F)(F)C(O)=O>>[CH2:1]([C:5]1[C:6]2[N:20]=[C:19]([C:21]3[CH:22]=[C:23]([CH3:37])[C:24]([O:25][CH2:26][C:27]([OH:29])=[O:28])=[C:34]([CH3:36])[CH:35]=3)[O:18][C:7]=2[N:8]=[C:9]([O:11][CH2:12][CH2:13][C:14]([F:17])([F:16])[F:15])[N:10]=1)[CH:2]([CH3:4])[CH3:3]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 71187267HCID 71187267, compound

Product 1

HCID 71203163HCID 71203163, compoundYield 56%

Procedure

Analogously to example 1 (j), the reaction of 8 mg of tert-butyl {4-[7-isobutyl-5-(3,3,3-trifluoropropoxy)oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy}acetate with trifluoroacetic acid gave 4 mg (56%) of the title compound.

Sources & evidence

ORD record: ord-280053a7f3c74f40ba0ac88622548ada
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09321787B2

Reaction notes

Loading…