3-Chlorophenol → HCID 71186246, compound

HRID 633628Notes

Reaction equation

HRID 633628 reaction equation
CS([C:5]1[N:6]=[C:7]([CH2:31][CH2:32][CH3:33])[C:8]2[N:13]=[C:12]([C:14]3[CH:28]=[C:27]([CH3:29])[C:17]([O:18][CH2:19][C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])=[C:16]([CH3:30])[CH:15]=3)[O:11][C:9]=2[N:10]=1)(=O)=O.[Cl:34][C:35]1[CH:36]=[C:37]([OH:41])[CH:38]=[CH:39][CH:40]=1>>[Cl:34][C:35]1[CH:36]=[C:37]([CH:38]=[CH:39][CH:40]=1)[O:41][C:5]1[N:6]=[C:7]([CH2:31][CH2:32][CH3:33])[C:8]2[N:13]=[C:12]([C:14]3[CH:28]=[C:27]([CH3:29])[C:17]([O:18][CH2:19][C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])=[C:16]([CH3:30])[CH:15]=3)[O:11][C:9]=2[N:10]=1

Participants

3

Reactant 2

HCID 79333-ChlorophenolHCID 71186232HCID 71186232, compound

Product 1

HCID 71186246HCID 71186246, compoundYield 100%

Procedure

Analogously to example 1 (i), the reaction of 104 mg of tert-butyl [4-(5-methanesulfonyl-7-propyloxazolo[5,4-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]acetate with 3-chlorophenol gave 115 mg (100%) of the title compound.

Sources & evidence

ORD record
ord-c829b744d0d84ce68ac99b0759653405
Source dataset
uspto-grants-2016_04
Patent number
US09321787B2

Reaction notes

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