Trifluoroacetic acid → HCID 71186286, compound

HRID 633629Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH:35]=[CH:36][CH:37]=1)[O:5][C:6]1[N:7]=[C:8]([CH2:32][CH2:33][CH3:34])[C:9]2[N:14]=[C:13]([C:15]3[CH:29]=[C:28]([CH3:30])[C:18]([O:19][CH2:20][C:21]([O:23]C(C)(C)C)=[O:22])=[C:17]([CH3:31])[CH:16]=3)[O:12][C:10]=2[N:11]=1.FC(F)(F)C(O)=O>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:35]=[CH:36][CH:37]=1)[O:5][C:6]1[N:7]=[C:8]([CH2:32][CH2:33][CH3:34])[C:9]2[N:14]=[C:13]([C:15]3[CH:16]=[C:17]([CH3:31])[C:18]([O:19][CH2:20][C:21]([OH:23])=[O:22])=[C:28]([CH3:30])[CH:29]=3)[O:12][C:10]=2[N:11]=1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 71186246HCID 71186246, compound

Product 1

HCID 71186286HCID 71186286, compoundYield 43%

Procedure

Analogously to example 1 (j), the reaction of 115 mg of tert-butyl {4-[5-(3-chlorophenoxy)-7-propyloxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy}acetate with trifluoroacetic acid gave 44 mg (43%) of the title compound.

Sources & evidence

ORD record: ord-47ec8422aadc409eb8d6a7bcbf96847d
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09321787B2

Reaction notes

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