Phosphorus oxychloride → HCID 86675959, compound

HRID 633631Notes

Reaction equation

HRID 633631 reaction equation
[Cl:1][C:2]1[CH:28]=[CH:27][C:5]([CH2:6][C:7]2[N:8]=[C:9](O)[C:10]3[N:15]=[C:14]([C:16]4[CH:21]=[C:20]([CH3:22])[C:19]([O:23][CH3:24])=[C:18]([CH3:25])[CH:17]=4)[O:13][C:11]=3[N:12]=2)=[CH:4][CH:3]=1.P(Cl)(Cl)([Cl:31])=O>>[Cl:31][C:9]1[C:10]2[N:15]=[C:14]([C:16]3[CH:17]=[C:18]([CH3:25])[C:19]([O:23][CH3:24])=[C:20]([CH3:22])[CH:21]=3)[O:13][C:11]=2[N:12]=[C:7]([CH2:6][C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:28][CH:27]=2)[N:8]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178489872HCID 178489872, compound

Product 1

HCID 86675959HCID 86675959, compound

Procedure

10 g of 5-(4-chlorobenzyl)-2-(4-methoxy-3,5-dimethylphenyl)oxazolo[5,4-d]pyrimidin-7-ol and 50 ml of phosphorus oxychloride were heated at 90° C. for 5 h. The mixture was then allowed to cool. The solid formed was filtered off with suction, washed with diethyl ether and dried. This gave 10.4 g (99%) of the title compound.

Workup

  1. temperatureto cool
  2. customThe solid formed
  3. filtrationwas filtered off with suction
  4. washwashed with diethyl ether
  5. customdried

Sources & evidence

ORD record
ord-6ccfbcd6e824499586f42a919c4b59f6
Source dataset
uspto-grants-2016_04
Patent number
US09321787B2

Reaction notes

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