Boron tribromide → HCID 136413237, compound

HRID 633638Notes

Reaction equation

HRID 633638 reaction equation
[Cl:1][C:2]1[CH:30]=[CH:29][C:5]([CH2:6][C:7]2[N:8]=[C:9]([CH:26]([CH3:28])[CH3:27])[C:10]3[N:15]=[C:14]([C:16]4[CH:21]=[C:20]([CH3:22])[C:19]([O:23]C)=[C:18]([CH3:25])[CH:17]=4)[O:13][C:11]=3[N:12]=2)=[CH:4][CH:3]=1.B(Br)(Br)Br>>[Cl:1][C:2]1[CH:30]=[CH:29][C:5]([CH2:6][C:7]2[N:8]=[C:9]([CH:26]([CH3:27])[CH3:28])[C:10]3[N:15]=[C:14]([C:16]4[CH:21]=[C:20]([CH3:22])[C:19]([OH:23])=[C:18]([CH3:25])[CH:17]=4)[O:13][C:11]=3[N:12]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 25134Boron tribromideHCID 71186593HCID 71186593, compound

Product 1

HCID 136413237HCID 136413237, compoundYield 70%

Procedure

Analogously to example 1 (e), the reaction of 170 mg of 5-(4-chlorobenzyl)-7-isopropyl-2-(4-methoxy-3,5-dimethylphenyl)oxazolo[5,4-d]pyrimidine with boron tribromide gave 115 mg (70%) of the title compound.

Sources & evidence

ORD record
ord-24172ddbd90b4ff1b8c2dea989fac5e3
Source dataset
uspto-grants-2016_04
Patent number
US09321787B2

Reaction notes

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