Trifluoroacetic acid → HCID 71203173, compound

HRID 633639Notes

Reaction equation

HRID 633639 reaction equation
[Cl:1][C:2]1[CH:37]=[CH:36][C:5]([CH2:6][C:7]2[N:8]=[C:9]([CH:33]([CH3:35])[CH3:34])[C:10]3[N:15]=[C:14]([C:16]4[CH:30]=[C:29]([CH3:31])[C:19]([O:20][CH2:21][C:22]([O:24]C(C)(C)C)=[O:23])=[C:18]([CH3:32])[CH:17]=4)[O:13][C:11]=3[N:12]=2)=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][C:7]2[N:8]=[C:9]([CH:33]([CH3:34])[CH3:35])[C:10]3[N:15]=[C:14]([C:16]4[CH:17]=[C:18]([CH3:32])[C:19]([O:20][CH2:21][C:22]([OH:24])=[O:23])=[C:29]([CH3:31])[CH:30]=4)[O:13][C:11]=3[N:12]=2)=[CH:36][CH:37]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 71203144HCID 71203144, compound

Product 1

HCID 71203173HCID 71203173, compoundYield 123.7%

Procedure

Analogously to example 1 (j), the reaction of 67 mg of tert-butyl {4-[5-(4-chlorobenzyl)-7-isopropyloxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy}acetate with trifluoroacetic acid gave 74 mg (100%) of the title compound.

Sources & evidence

ORD record
ord-0afe9794cc9043458d3d1dbfe3a5c045
Source dataset
uspto-grants-2016_04
Patent number
US09321787B2

Reaction notes

Loading…