HRID63366

反应详情

EQUATION

反应方程式

REACTANTS

反应物

$结构：O=C(O)/C=C\C(=O)O$

HCID444266

Maleic acid

C4H4O4

结构：CCc1cncc(Nc2cc(COc3ccc(NC(=O)Nc4cc(C(C)(C)C)nn4-c4ccc(C)cc4)c4ccccc34)ccn2)n1

HCID91827605

未命名化合物

PRODUCTS

生成物

$结构：CCc1cncc(Nc2cc(COc3ccc(NC(=O)Nc4cc(C(C)(C)C)nn4-c4ccc(C)cc4)c4ccccc34)ccn2)n1.O=C(O)/C=C\C(=O)O$

HCID118305960

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((6-ethylpyrazin-2-yl)amino)pyridin-4-yl)methoxy)naphthalen-1-yl)urea was dissolved in THF (40 vol.) at 50° C. and 1 eq of maleic acid was added. The sample was left to mature between RT and 50° C. (4 h at each temperature) for 2 days. Solid material (Form 1) was isolated.

WORKUP

后处理

customSolid material (Form 1) was isolated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-71ee58a84f8c49449d160d095538bf41
来源数据集: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09447076B2
来源说明: uspto-grants-2016_09

反应 SMILES

[C:1]([C:5]1[CH:9]=[C:8]([NH:10][C:11]([NH:13][C:14]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[C:17]([O:24][CH2:25][C:26]3[CH:31]=[CH:30][N:29]=[C:28]([NH:32][C:33]4[CH:38]=[N:37][CH:36]=[C:35]([CH2:39][CH3:40])[N:34]=4)[CH:27]=3)=[CH:16][CH:15]=2)=[O:12])[N:7]([C:41]2[CH:46]=[CH:45][C:44]([CH3:47])=[CH:43][CH:42]=2)[N:6]=1)([CH3:4])([CH3:3])[CH3:2].[C:48]([OH:55])(=[O:54])/[CH:49]=[CH:50]\[C:51]([OH:53])=[O:52]>C1COCC1>[C:48]([OH:55])(=[O:54])/[CH:49]=[CH:50]\[C:51]([OH:53])=[O:52].[C:1]([C:5]1[CH:9]=[C:8]([NH:10][C:11]([NH:13][C:14]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[C:17]([O:24][CH2:25][C:26]3[CH:31]=[CH:30][N:29]=[C:28]([NH:32][C:33]4[CH:38]=[N:37][CH:36]=[C:35]([CH2:39][CH3:40])[N:34]=4)[CH:27]=3)=[CH:16][CH:15]=2)=[O:12])[N:7]([C:41]2[CH:42]=[CH:43][C:44]([CH3:47])=[CH:45][CH:46]=2)[N:6]=1)([CH3:4])([CH3:2])[CH3:3]