反应详情

温度

100 °C

Synthesis of 2-(2,4-dimethyl-6-(pyridin-4-yl)phenoxy)acetohydrazide: 2-(2,4-dimethyl-6-(pyridin-4-yl)phenoxy)acetate (0.1 g, 0.37 mmol) was dissolved in EtOH. Hydrazine monohydrate (0.13 g, 2.63 mmol) was added thereto, followed by stirring at 100° C. for 16 hours under reflux. After the completion of the reaction, the reaction mixture was concentrated under reduced pressure, and purified by column chromatography to obtain 2-(2,4-dimethyl-6-(pyridin-3-yl)phenoxy)acetohydrazide (0.1 g, 100%).

1. temperatureunder reflux
2. customAfter the completion of the reaction
3. concentrationthe reaction mixture was concentrated under reduced pressure
4. custompurified by column chromatography