Hydrazine hydrate (1:1) → HCID 90002539, compound

HRID 63368Notes

Reaction equation

HRID 63368 reaction equation
[CH3:1][C:2]1[CH:13]=[C:12]([CH3:14])[CH:11]=[C:10]([C:15]2[CH:20]=[CH:19]N=C[CH:16]=2)[C:3]=1[O:4][CH2:5][C:6]([NH:8][NH2:9])=[O:7].CC1C=C(C)C=C(C2C=C[N:37]=[CH:36]C=2)C=1OCC([O-])=O.O.NN>CCO>[CH3:1][C:2]1[CH:13]=[C:12]([CH3:14])[CH:11]=[C:10]([C:15]2[CH:16]=[N:37][CH:36]=[CH:19][CH:20]=2)[C:3]=1[O:4][CH2:5][C:6]([NH:8][NH2:9])=[O:7]

Participants

5

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 397330862-(2,4-Dimethyl-6-(pyridin-4-yl)phenoxy)acetateHCID 90002233HCID 90002233, compound

Product 1

HCID 90002539HCID 90002539, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
100 °C

Procedure

Synthesis of 2-(2,4-dimethyl-6-(pyridin-4-yl)phenoxy)acetohydrazide: 2-(2,4-dimethyl-6-(pyridin-4-yl)phenoxy)acetate (0.1 g, 0.37 mmol) was dissolved in EtOH. Hydrazine monohydrate (0.13 g, 2.63 mmol) was added thereto, followed by stirring at 100° C. for 16 hours under reflux. After the completion of the reaction, the reaction mixture was concentrated under reduced pressure, and purified by column chromatography to obtain 2-(2,4-dimethyl-6-(pyridin-3-yl)phenoxy)acetohydrazide (0.1 g, 100%).

Workup

  1. temperatureunder reflux
  2. customAfter the completion of the reaction
  3. concentrationthe reaction mixture was concentrated under reduced pressure
  4. custompurified by column chromatography

Sources & evidence

ORD record
ord-40ed1a5e768a43db956f52d2e6453272
Source dataset
uspto-grants-2016_09
Patent number
US09447083B2

Reaction notes

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