Hydrazine → HCID 90002256, compound

HRID 63369Notes

Reaction equation

HRID 63369 reaction equation
[CH3:1][C:2]1[CH:13]=[CH:12][CH:11]=[C:10]([CH:14]2[CH2:18][CH2:17][O:16][CH2:15]2)[C:3]=1[O:4][CH2:5][C:6]([NH:8][NH2:9])=[O:7].CC1C=CC=C(C2CCOC2)C=1OCC(OC)=O.NN>CCO>[O:16]1[CH:17]=[CH:18][C:14]([C:10]2[CH:11]=[CH:12][CH:13]=[C:2]([CH3:1])[C:3]=2[O:4][CH2:5][C:6]([NH:8][NH2:9])=[O:7])=[CH:15]1

Participants

5

Reactant 3

HCID 9321HydrazineHCID 90002242HCID 90002242, compoundHCID 900026992-(2-Methyl-6-(tetrahydrofuran-3-yl)phenoxy)acetohydrazide

Product 1

HCID 90002256HCID 90002256, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
100 °C

Procedure

Synthesis of 2-(2-methyl-6-(tetrahydrofuran-3-yl)phenoxy)acetohydrazide: methyl 2-(2-methyl-6-(tetrahydrofuran-3-yl)phenoxy)acetate (141 mg, 0.56 mmol) and hydrazine (0.03 mL, 0.6 mmol) were dissolved in EtOH 2 mL, followed by stirring at 100° C. for 12 hours. After the completion of the reaction, the reaction mixture was concentrated under reduced pressure to obtain 2-(2-(furan-3-yl)-6-methylphenoxy)acetohydrazide (127 mg, 90%).

Workup

  1. customAfter the completion of the reaction
  2. concentrationthe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-1bbfb45c28f84f6cbc642f992f912dc3
Source dataset
uspto-grants-2016_09
Patent number
US09447083B2

Reaction notes

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