Dimethylamine → HCID 12060373, compound

HRID 633743Notes

Reaction equation

HRID 633743 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1.C(O)C.[CH3:14][NH:15][CH3:16]>O1CCCC1.O>[CH3:14][N:15]([CH3:16])[C:2]1[N:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1

Participants

6

Reactant 3

HCID 674DimethylamineHCID 702EthanolHCID 27796981-(6-Chloropyridin-3-yl)ethan-1-one

Product 1

HCID 12060373HCID 12060373, compoundYield 99%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

500 mg (2.89 mmol) of 1-(6-chloropyrid-3-yl)ethanone, 2 mL of ethanol and 7.23 mL (14.46 mmol) of 2 M dimethylamine in tetrahydrofuran are placed in a 20 mL microwave reactor. The solution is irradiated with microwaves for 10 minutes at 130° C. The mixture obtained is taken up in water and extracted with ethyl acetate. The organic phase is dried over sodium sulfate and evaporated to dryness to give 470 mg of 1-(6-dimethylaminopyrid-3-yl)ethanone, the characteristics of which are as follows:

Workup

  1. customThe solution is irradiated with microwaves for 10 minutes at 130° C
  2. customThe mixture obtained
  3. extractionextracted with ethyl acetate
  4. dry with materialThe organic phase is dried over sodium sulfate
  5. customevaporated to dryness

Sources & evidence

ORD record
ord-f4d6ba02b39f40a18e46cf037615f523
Source dataset
uspto-grants-2016_04
Patent number
US09321790B2

Reaction notes

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