Hydrogen Bromide → 2-Bromo-1-(6-methylpyridin-3-yl)ethanone hydrobromide

HRID 633747Notes

Reaction equation

HRID 633747 reaction equation
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1.[BrH:11].BrBr>C(O)(=O)C>[BrH:11].[Br:11][CH2:9][C:8]([C:5]1[CH:6]=[N:7][C:2]([CH3:1])=[CH:3][CH:4]=1)=[O:10]

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 952923-Acetyl-6-methylpyridine

Product 1

HCID 454805112-Bromo-1-(6-methylpyridin-3-yl)ethanone hydrobromide

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

500 mg (3.59 mmol) of 1-(6-methylpyrid-3-yl)ethanone, 590 μl (3.59 mmol) of hydrobromic acid, 204 μl (3.95 mmol) of bromine and 10 mL of glacial acetic acid were used in the reaction. After precipitation with ethyl ether and filtration, 1.02 g of 2-bromo-1-(6-methylpyrid-3-yl)ethanone hydrobromide are obtained, the characteristics of which are as follows:

Workup

  1. customAfter precipitation
  2. filtrationwith ethyl ether and filtration, 1.02 g of 2-bromo-1-(6-methylpyrid-3-yl)ethanone hydrobromide
  3. customare obtained

Sources & evidence

ORD record
ord-eee58b6607064dc58e5a858551127640
Source dataset
uspto-grants-2016_04
Patent number
US09321790B2

Reaction notes

Loading…