Hydrogen Bromide → HCID 118106272, compound

HRID 633765Notes

Reaction equation

HRID 633765 reaction equation
[CH3:1][NH:2][C:3]1[N:8]=[CH:7][C:6]([C:9](=[O:11])[CH3:10])=[CH:5][CH:4]=1.[BrH:12].BrBr>C(O)(=O)C>[Br:12][CH2:10][C:9]([C:6]1[CH:7]=[N:8][C:3]([NH:2][CH3:1])=[CH:4][CH:5]=1)=[O:11]

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 18715057HCID 18715057, compound

Product 1

HCID 118106272HCID 118106272, compoundYield 63.8%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

380 mg (2.53 mmol) of 1-(6-methylaminopyrid-3-yl)ethanone, 416 μl (2.53 mmol) of hydrobromic acid, 130 μl (2.53 mmol) of bromine and 5 mL of glacial acetic acid were used in the reaction. After precipitation with ethyl ether and filtration, the precipitate is taken up in water. The solution is basified with saturated NaHCO3 solution. The precipitate formed is filtered off, washed with water and then dried under vacuum. 370 mg of 2-bromo-1-(6-methylaminopyrid-3-yl)ethanone are obtained, the characteristics of which are as follows:

Workup

  1. customAfter precipitation
  2. filtrationwith ethyl ether and filtration
  3. customThe precipitate formed
  4. filtrationis filtered off
  5. washwashed with water
  6. customdried under vacuum

Sources & evidence

ORD record
ord-1dfc804ed41f4ac993b9d14f314b2b1f
Source dataset
uspto-grants-2016_04
Patent number
US09321790B2

Reaction notes

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