3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid → 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid [1-(8-methoxy-2,3-dihydro-furo[3,2-c]quinolin-2-ylmethyl)-azetidin-3-yl]-amide

HRID 633826ノート

反応式

HRID 633826 の反応式
Br[CH2:2][CH:3]1[O:15][C:14]2[C:13]3[CH:12]=[C:11]([O:16][CH3:17])[CH:10]=[CH:9][C:8]=3[N:7]=[CH:6][C:5]=2[CH2:4]1.C(OC([N:25]1[CH2:28][CH:27]([NH2:29])[CH2:26]1)=O)(C)(C)C.[O:30]=[C:31]1[NH:36][C:35]2[CH:37]=[C:38]([C:41](O)=[O:42])[CH:39]=[CH:40][C:34]=2[S:33][CH2:32]1>>[CH3:17][O:16][C:11]1[CH:10]=[CH:9][C:8]2[N:7]=[CH:6][C:5]3[CH2:4][CH:3]([CH2:2][N:25]4[CH2:26][CH:27]([NH:29][C:41]([C:38]5[CH:39]=[CH:40][C:34]6[S:33][CH2:32][C:31](=[O:30])[NH:36][C:35]=6[CH:37]=5)=[O:42])[CH2:28]4)[O:15][C:14]=3[C:13]=2[CH:12]=1

参加物

4

反応物 3

HCID 7609933-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acidHCID 1516507Tert-butyl 3-aminoazetidine-1-carboxylateHCID 867307082-Bromomethyl-8-methoxy-2,3-dihydro-furo[3,2-c]quinoline

生成物 1

HCID 714755043-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid [1-(8-methoxy-2,3-dihydro-furo[3,2-c]quinolin-2-ylmethyl)-azetidin-3-yl]-amide

実験手順

The titled compound is prepared as a white lyophilized powder following Scheme 1 and in analogy to Example 1 using 2-bromomethyl-8-methoxy-2,3-dihydro-furo[3,2-c]quinoline, 3-amino-azetidine-1-carboxylic acid tert-butyl ester and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting material.

出典と根拠

ORDレコード
ord-9338297564304c6597d6b6b766d207d2
出典データセット
uspto-grants-2016_04
特許番号
US09321788B2

反応ノート

読み込み中…