HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid → 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid [1-(8-methoxy-2,3-dihydro-furo[3,2-c]quinolin-2-ylmethyl)-azetidin-3-yl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid | HCID 760993 | — |
| Reactant | Tert-butyl 3-aminoazetidine-1-carboxylate | HCID 1516507 | — |
| Reactant | 2-Bromomethyl-8-methoxy-2,3-dihydro-furo[3,2-c]quinoline | HCID 86730708 | — |
| Product | 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid [1-(8-methoxy-2,3-dihydro-furo[3,2-c]quinolin-2-ylmethyl)-azetidin-3-yl]-amide | HCID 71475504 | — |
Reaction Steps
The titled compound is prepared as a white lyophilized powder following Scheme 1 and in analogy to Example 1 using 2-bromomethyl-8-methoxy-2,3-dihydro-furo[3,2-c]quinoline, 3-amino-azetidine-1-carboxylic acid tert-butyl ester and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting material.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321788B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-9338297564304c6597d6b6b766d207d2 |
| Source note | uspto-grants-2016_04 |