HRID633832

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID760993

3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid

C9H7NO3S

HCID4913064

未命名化合物

HCID86730711

未命名化合物

PRODUCTS

生成物

结构：COC(=O)C1CC(NC(=O)c2ccc3c(c2)NC(=O)CS3)CN1CC1CSc2cnc3ccc(OC)cc3c2C1

HCID71118894

未命名化合物

PROCEDURE

实验过程

The titled compound is prepared as an orange viscous oil following Scheme 1 and in analogy to Example 1 using 3-bromomethyl-6-methoxy-3,4-dihydro-2H-1-thia-9-aza-phenanthrene, 4-amino-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting material.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-52b482dc85ec4f39935a7dd782bed7e7
来源数据集: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09321788B2
来源说明: uspto-grants-2016_04

反应 SMILES

Br[CH2:2][CH:3]1[CH2:16][C:15]2[C:14]3[C:9](=[CH:10][CH:11]=[C:12]([O:17][CH3:18])[CH:13]=3)[N:8]=[CH:7][C:6]=2[S:5][CH2:4]1.[CH3:19][O:20][C:21]([CH:23]1[CH2:27][CH:26]([NH2:28])[CH2:25][N:24]1C(OC(C)(C)C)=O)=[O:22].[O:36]=[C:37]1[NH:42][C:41]2[CH:43]=[C:44]([C:47](O)=[O:48])[CH:45]=[CH:46][C:40]=2[S:39][CH2:38]1>>[CH3:19][O:20][C:21]([CH:23]1[CH2:27][CH:26]([NH:28][C:47]([C:44]2[CH:45]=[CH:46][C:40]3[S:39][CH2:38][C:37](=[O:36])[NH:42][C:41]=3[CH:43]=2)=[O:48])[CH2:25][N:24]1[CH2:2][CH:3]1[CH2:16][C:15]2[C:14]3[C:9](=[CH:10][CH:11]=[C:12]([O:17][CH3:18])[CH:13]=3)[N:8]=[CH:7][C:6]=2[S:5][CH2:4]1)=[O:22]