Hydrochloric Acid → 3-[(4-Fluorophenoxy)methyl]piperidine hydrochloride

HRID 633877Notes

Reaction equation

HRID 633877 reaction equation
[F:1][C:2]1[CH:22]=[CH:21][C:5]([O:6][CH2:7][CH:8]2[CH2:13][CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9]2)=[CH:4][CH:3]=1.[ClH:23]>ClCCl.O1CCOCC1>[ClH:23].[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH2:7][CH:8]2[CH2:13][CH2:12][CH2:11][NH:10][CH2:9]2)=[CH:21][CH:22]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67154710Tert-butyl 3-[(4-fluorophenoxy)methyl]piperidine-1-carboxylate

Product 1

HCID 171780143-[(4-Fluorophenoxy)methyl]piperidine hydrochloride

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a cooled solution of tert-butyl 3-[(4-fluorophenoxy)methyl]piperidine-1-carboxylate (300 mg, 1.03 mmol; which may be prepared as described in Step 1) in dichloromethane (6.8 mL) was added dropwise HCl 4N in dioxane (5.0 mL). The solution was warmed to room temperature and stirred for 1 h. The solvent was evaporated under reduced pressure to give the title compound (267 mg, quantitative) as a white solid.

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-fa9e39bd62424250be6410330afb9999
Source dataset
uspto-grants-2016_04
Patent number
US09321769B2

Reaction notes

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