Hydrochloric Acid → HCID 67154694, compound

HRID 633883Notes

Reaction equation

HRID 633883 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([CH:7]2[CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8]2)[N:3]=1.[ClH:18]>ClCCl.O1CCOCC1>[ClH:18].[NH:9]1[CH2:10][CH:7]([C:4]2[N:3]=[C:2]([CH3:1])[O:6][N:5]=2)[CH2:8]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67154640Tert-butyl 3-(5-methyl-1,2,4-oxadiazol-3-yl)azetidine-1-carboxylate

Product 1

HCID 67154694HCID 67154694, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a cooled solution of tert-butyl 3-(5-methyl-1,2,4-oxadiazol-3-yl)azetidine-1-carboxylate (97 mg, 0.41 mmol; which may be prepared as described in Step 4) in dichloromethane was added dropwise HCl 4N in dioxane (2.0 mL). The solution was warmed to room temperature and stirred for 1 h. The solvent was evaporated under reduced pressure to give the title compound (101 mg, quantitative) as a white solid. The product was used in the next step without further analysis.

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-63b6c69f393d4088aeb70a274bf990a5
Source dataset
uspto-grants-2016_04
Patent number
US09321769B2

Reaction notes

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