Thionyl Chloride → HCID 21585204, compound

HRID 633940Notes

Reaction equation

HRID 633940 reaction equation
S(Cl)([Cl:3])=O.[S:5]1[CH:9]=[CH:8][CH:7]=[C:6]1[CH2:10][CH2:11][CH2:12]O>C1COCC1>[Cl:3][CH2:12][CH2:11][CH2:10][C:6]1[S:5][CH:9]=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 131098663-(Thiophen-2-yl)propan-1-ol

Product 1

HCID 21585204HCID 21585204, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
50 °C

Procedure

Thionyl chloride (420 μL, 5.7 mmol) was added to a solution of 3-(2-thienyl)propanol (682.0 mg, 4.8 mmol) in THF (3 mL) at room temperature. The reaction mixture was stirred at 50° C. for 2 hours and then concentrated to dryness to afford the title compound as a brown oil. The product was used in the next step without further purification.

Workup

  1. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-d5ccbb785c8443e4ab2bfbd0aa4e7c8b
Source dataset
uspto-grants-2016_04
Patent number
US09321769B2

Reaction notes

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