Hydrochloric Acid → HCID 67154562, compound

HRID 633953Notes

Reaction equation

HRID 633953 reaction equation
[ClH:1].[S:2]1[C:6]([CH2:7][O:8][CH:9]2[CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10]2)=[CH:5][N:4]=[CH:3]1>C(OCC)C>[ClH:1].[NH:11]1[CH2:12][CH:9]([O:8][CH2:7][C:6]2[S:2][CH:3]=[N:4][CH:5]=2)[CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68338107tert-Butyl 3-(thiazol-5-ylmethoxy)-azetidine-1-carboxylate

Product 1

HCID 67154562HCID 67154562, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

A solution of HCl in diethylether (2N, 5.5 mL) was added to a solution of tert-butyl 3-(thiazol-5-ylmethoxy)-azetidine-1-carboxylate (150 mg, 0.55 mmol) in diethylether (2 mL) at room temperature. The reaction mixture was stirred 30 minutes then concentrated to dryness. After trituration in diethyl ether (10 mL), the title compound was obtained as a yellow solid (113 mg, quantitative).

Workup

  1. concentrationthen concentrated to dryness

Sources & evidence

ORD record
ord-18436d2da3524894b492a962acc2dd24
Source dataset
uspto-grants-2016_04
Patent number
US09321769B2

Reaction notes

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