反应详情

A solution of 2-(1H-indole-5-carbonyl)-N-(4-methoxybenzyl)hydrazinecarbothioamide (0.1 g, 0.284 mmol) and EDC.HCl (0.109 g, 0.586 mmol) in toluene (10 mL) was heated to reflux for 12 h. The mixture was cooled to RT. The supernatant layer was decanted and the sticky material in the bottom was dissolved in EtOAc (20 mL). The organic layer was washed with water, brine, dried, filtered and concentrated to give the crude material. MS (ESI, pos. ion) m/z: 321 (M+1).

1. temperatureto reflux for 12 h
2. customThe supernatant layer was decanted
3. dissolutionthe sticky material in the bottom was dissolved in EtOAc (20 mL)
4. washThe organic layer was washed with water, brine
5. customdried
6. filtrationfiltered
7. concentrationconcentrated