5-(3-(4-(isopropylamino)pyrimidin-2-yl)-1-tosyl-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,3,4-oxadiazol-2-amine → 5-(3-(4-(isopropylamino)pyrimidin-2-yl)-1-tosyl-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine

Participants

Reaction Steps

A solution of 5-(3-(4-(isopropylamino)pyrimidin-2-yl)-1-tosyl-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,3,4-oxadiazol-2-amine (220 mg, 0.36 mmol) in TFA (1.1 mL) was heated at 100° C. in a microwave for 30 min. The mixture was cooled to RT and TFA was removed in vacuo. The residue was washed with Et2O to give the crude material (150 mg, 85%). MS (ESI, pos. ion) m/z: 489.7 (M+1).

Provenance & Evidence