HRID634103

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccc(CNc2nnc(-c3ccc4c(c3)c(-c3nccc(NC(C)C)n3)cn4S(=O)(=O)c3ccc(C)cc3)o2)cc1

HCID68328546

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(S(=O)(=O)n2cc(-c3nccc(NC(C)C)n3)c3cc(-c4nnc(N)o4)ccc32)cc1

HCID68328311

未命名化合物

收率 85.1%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6422

未命名化合物

PROCEDURE

实验过程

A solution of 5-(3-(4-(isopropylamino)pyrimidin-2-yl)-1-tosyl-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,3,4-oxadiazol-2-amine (220 mg, 0.36 mmol) in TFA (1.1 mL) was heated at 100° C. in a microwave for 30 min. The mixture was cooled to RT and TFA was removed in vacuo. The residue was washed with Et2O to give the crude material (150 mg, 85%). MS (ESI, pos. ion) m/z: 489.7 (M+1).

WORKUP

后处理

customTFA was removed in vacuo
washThe residue was washed with Et2O