HRID634149
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
产物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 120 °C
PROCEDURE
实验过程
A mixture of tert-butyl 3-(quinolin-3-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate (80 mg, 170 μmol), 2-bromo-5-(methylthio)-1,3,4-thiadiazole (54 mg, 255 μmol), Pd(PPh3)4 (9.8 mg, 8.5 μmol) and potassium carbonate (71 mg, 510 μmol) in dioxane (1.0 mL) was added H2O (0.2 mL). The reaction was heated in a microwave at 120° C. for 70 min. The solvent was then removed and the residue was purified with silica gel chromatography to give tert-butyl 5-(5-(methylthio)-1,3,4-thiadiazol-2-yl)-3-(quinolin-3-yl)-1H-indole-1-carboxylate (41 mg, 51%). MS (ESI, pos. ion) m/z: 475 (M+1).
WORKUP
后处理
- customThe solvent was then removed
- customthe residue was purified with silica gel chromatography