HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → 3-(Hydroxymethyl)-4-phenyl-1H-isochromen-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Phenylboronic Acid | HCID 66827 | — |
| Reactant | 4-bromo-3-(hydroxymethyl)-1H-isochromen-1-one | HCID 16050022 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | 3-(Hydroxymethyl)-4-phenyl-1H-isochromen-1-one | HCID 21463276 | 36% |
Reaction Steps
The title compound was made in a similar way as that of the intermediate B1, starting from 4-bromo-3-(hydroxymethyl)-1H-isochromen-1-one (Intermediate A1, 0.8 g, 3.14 mmol), phenylboronic acid (0.467 g, 3.83 mmol), Pd(PPh3)4 (0.181 g, 0.379 mmol) and Cs2CO3 (3.29 g, 10.11 mmol) to afford the title compound (210 mg, 36%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321776B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-1414882b74254135b639688dbb015d93 |
| Source note | uspto-grants-2016_04 |