反应详情

Tert-butyl 4-(3-(1-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-1-oxo-1H-isochromen-4-yl)-5,6-dihydropyridine-1(2H)-carboxylate (Intermediate D14, 1.5 g, 2.441 mmol) was suspended in 1,4-Dioxane (5 ml) and 4 M HCl in dioxane (15.26 ml, 61.0 mmol) was added. The mixture was stirred at rt for 4 h, then volatiles were removed under reduced pressure to give title compound (1.56 g) as a light pink powder.

1. customvolatiles were removed under reduced pressure