HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1,2,3,6-Tetrahydropyridine-4-boronic acid, pinacol ester hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine-1-carboxylate | HCID 4642098 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | tert-Butyl methyl ether | HCID 15413 | — |
| Product | 1,2,3,6-Tetrahydropyridine-4-boronic acid, pinacol ester hydrochloride | HCID 49761084 | 90% |
Reaction Steps
tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate (2 g, 6.47 mmol) was suspended in MTBE (8.1 mL) and 2M HCl in Et2O (24 mL). The reaction was stirred rt overnight, the white precipitate formed collected by filtration and washed with Et2O to give the title compound (1.434 g, 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321776B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-76777c072ba54fb8bb2b8c2d6126188d |
| Source note | uspto-grants-2016_04 |