HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 634424Generated: October 30, 2026
Trifluoroacetic acid → HCID 178508724, compound
https://huagongshe.com/reaction/634424
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | N,1-bis(tetrahydro-2H-pyran-2-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | HCID 118131445 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 178508724 | HCID 178508724 | 93.5% |
Reaction Steps
To a solution of N,1-bis(tetrahydro-2H-pyran-2-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (intermediate G15, 88 mg, 0.237 mmol) in EtOH (5 mL), water (0.5 mL) was added. Then 2,2,2-trifluoroacetic acid (0.3 ml, 0.237 mmol) was added and the mixture was stirred at 80° C. overnight. Solvent was removed to give the title compound (45 mg, 93%) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09321776B2 |
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| Source dataset | uspto-grants-2016_04 |
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| ORD ID | ord-9047d79d4a5443a480db1dc4e63ef7aa |
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| Source note | uspto-grants-2016_04 |
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