Trifluoroacetic acid → HCID 178508724, compound

HRID 634424Notes

Reaction equation

HRID 634424 reaction equation
O1CCCCC1[NH:7][C:8]1[N:13]=[CH:12][N:11]=[C:10]2[N:14](C3CCCCO3)[N:15]=[C:16]([C:17]([F:20])([F:19])[F:18])[C:9]=12.FC(F)(F)C(O)=O>CCO.O>[F:19][C:17]([F:18])([F:20])[C:16]1[C:9]2[C:10](=[N:11][CH:12]=[N:13][C:8]=2[NH2:7])[NH:14][N:15]=1

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 118131445N,1-bis(tetrahydro-2H-pyran-2-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Product 1

HCID 178508724HCID 178508724, compoundYield 93.5%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of N,1-bis(tetrahydro-2H-pyran-2-yl)-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (intermediate G15, 88 mg, 0.237 mmol) in EtOH (5 mL), water (0.5 mL) was added. Then 2,2,2-trifluoroacetic acid (0.3 ml, 0.237 mmol) was added and the mixture was stirred at 80° C. overnight. Solvent was removed to give the title compound (45 mg, 93%) as a yellow solid.

Workup

  1. customSolvent was removed

Sources & evidence

ORD record
ord-9047d79d4a5443a480db1dc4e63ef7aa
Source dataset
uspto-grants-2016_04
Patent number
US09321776B2

Reaction notes

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