Potassium Carbonate → HCID 178424569, compound

HRID 634441Notes

Reaction equation

HRID 634441 reaction equation
[N:1]1[C:9]([S:10][CH2:11][C:12]2[O:13][C:14](=[O:28])[C:15]3[C:20]([C:21]=2[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[CH:19][CH:18]=[CH:17][CH:16]=3)=[C:8]2[C:4]([NH:5][CH:6]=[N:7]2)=[N:3][CH:2]=1.Br[CH2:30]C1OC(=O)C2C(C=1C1C=C(C)C=CC=1)=CC=CC=2.O.N1C(S)=C2C(NC=N2)=NC=1.C([O-])([O-])=O.[K+].[K+]>>[N:1]1[C:9]([S:10][CH2:11][C:12]2[O:13][C:14](=[O:28])[C:15]3[C:20]([C:21]=2[C:22]2[CH:23]=[C:24]([CH3:30])[CH:25]=[CH:26][CH:27]=2)=[CH:19][CH:18]=[CH:17][CH:16]=3)=[C:8]2[C:4]([NH:5][CH:6]=[N:7]2)=[N:3][CH:2]=1

Participants

5

Reactant 4

HCID 11430Potassium CarbonateHCID 1181310793-(Bromomethyl)-4-m-tolyl-1H-isochromen-1-one2×HCID 178519204HCID 178519204, compoundHCID 178527205HCID 178527205, compound

Product 1

HCID 178424569HCID 178424569, compoundYield 82%

Procedure

The title compound was made in a similar way as that of the compound of example 10, 3-(bromomethyl)-4-m-tolyl-1H-isochromen-1-one (intermediate C3, 64 mg, 0.194 mmol), 9H-purine-6-thiol hydrate (33 mg, 0.194 mmol) and K2CO3 (27 mg, 0.111 mmol) to give the title compound (64 mg, 82%).

Sources & evidence

ORD record
ord-3bd7b97576234aa18bddc6f27e628632
Source dataset
uspto-grants-2016_04
Patent number
US09321776B2

Reaction notes

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