反应详情

A stirred solution of 44.0 grams (0.18 mole) of ethyl (2-fluoro-4-chloro-phenyl)malonate and 9.6 grams (0.24 mole) of methylhydrazine in 150 mL of 2-propanol was heated at reflux for about 48 hours. After this time the reaction mixture was concentrated under reduced pressure to a residue. The residue was slurred in 80 mL of methylene chloride and filtered to collect 27.0 grams of 1-methyl-2-hydroxy-3-(2-fluoro-4-chlorophenyl)pyrazole.

1. temperatureat reflux for about 48 hours
2. concentrationAfter this time the reaction mixture was concentrated under reduced pressure to a residue
3. filtrationfiltered
4. customto collect 27.0 grams of 1-methyl-2-hydroxy-3-(2-fluoro-4-chlorophenyl)pyrazole