Methyl chloroformate → HCID 21260326, compound

HRID 634668Notes

Reaction equation

HRID 634668 reaction equation
Cl[C:2]([O:4][CH3:5])=[O:3].[F:6][C:7]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:8]=1[OH:14].[OH-].[Na+]>O>[F:6][C:7]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:8]=1[O:14][C:2]([O:4][CH3:5])=[O:3]

Participants

5

Reactant 3

HCID 6586Methyl chloroformateHCID 14798Sodium HydroxideHCID 1230512,4-Difluorophenol

Product 1

HCID 21260326HCID 21260326, compoundYield 98.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Methyl chloroformate (16.35 ml, 0.173 mol) was added to a solution of 2,4difluorophenol (25 g, 0.192 mol) and sodium hydroxide (8.1 g, 0.203 mol) in water (140 ml). The mixture was stirred at ambient temperature for 2 hours and then extracted with ethyl acetate. The extract was washed with water, dried (MgSO4) and the volatiles removed by evaporation to give 2,4-difluoro-1-methoxycarbonyloxybenzene (32 g, 89%).

Workup

  1. extractionextracted with ethyl acetate
  2. washThe extract was washed with water
  3. dry with materialdried (MgSO4)
  4. customthe volatiles removed by evaporation

Sources & evidence

ORD record
ord-fa396c3647d84df584f80d0a1e1efd23
Source dataset
uspto-grants-2001_02
Patent number
US06184225B2

Reaction notes

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