Nitric Acid → HCID 21260309, compound

HRID 634669Notes

Reaction equation

HRID 634669 reaction equation
[N+:1]([O-:4])(O)=[O:2].[F:5][C:6]1[CH:11]=[C:10]([F:12])[CH:9]=[CH:8][C:7]=1[O:13][C:14]([O:16][CH3:17])=[O:15]>S(=O)(=O)(O)O>[F:12][C:10]1[CH:11]=[C:6]([F:5])[C:7]([O:13][C:14]([O:16][CH3:17])=[O:15])=[CH:8][C:9]=1[N+:1]([O-:4])=[O:2]

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 21260326HCID 21260326, compound

Product 1

HCID 21260309HCID 21260309, compoundYield 45%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent2×

Procedure

A mixture of concentrated nitric acid (4 ml) and concentrated sulphuric acid (4 ml) was added slowly to a cooled mixture of 2,4-difluoro-1-methoxycarbonyloxybenzene (50 g, 0.027 mol) in concentrated sulphuric acid (4 ml) such that the reaction temperature was maintained below 30° C. The mixture was stirred for a further 3 hours, diluted with ice/water and the precipitated product collected by filtration washed with water and dried to give 2,4-difluoro-5-methoxycarbonyloxy-1-nitrobenzene (2.8 g, 45%).

Workup

  1. temperaturewas maintained below 30° C
  2. filtrationthe precipitated product collected by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-2a0f1d7471634da49873f67dc4ca3902
Source dataset
uspto-grants-2001_02
Patent number
US06184225B2

Reaction notes

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